Figure 3 | Scientific Reports

Figure 3

From: Epstein–Barr virus peptides derived from latent cycle proteins alter NKG2A + NK cell effector function

Figure 3

EBV peptides trigger NKG2A + NK cell degranulation. (a) Gating strategy for the identification of NKG2A + and NKG2A−NK cells within PBMC. (b) Comparison of NKG2A-positive NK cell degranulation against target cells loaded with EBV peptides. Peptides were individually tested using 721.174 cells. HLA-A03 leader peptide and BZLF1 peptides were respectively used as controls for inhibition and no inhibition. All values have been normalized to “No Peptide”. One-way ANOVA showed significance when compared the leader peptide condition with the others, p < 0.05. (c) Comparison of NKG2A-NK cell degranulation against target cells loaded with EBV peptides. The same controls were used as in panel A and all values have been normalized to “No Peptide”. No significant differences were observed between the different conditions. Data shown is representative of 4 donors.

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